Amaryl M SR 2/500mg Tablet 30s (Box)

Amaryl M SR 2/500mg Tablet is a combination antidiabetic medicine belonging to two drug classes at once — a sulfonylurea and a biguanide — and it contains two active ingredients working together: glimepiride 2 mg and metformin hydrochloride 500 mg in a sustained-release (SR) form. If your doctor has prescribed this, it's worth knowing upfront that the most commonly reported effects include gastrointestinal symptoms such as nausea, diarrhea, or stomach discomfort, along with a risk of low blood sugar (hypoglycemia), particularly if meals are skipped. This is a prescription-only medicine, and it works by combining two complementary actions — helping your pancreas release more insulin while also improving how your body uses that insulin and reducing sugar production by the liver. Many people find combination tablets like this convenient, as they simplify a treatment routine that might otherwise involve two separate pills. As always, keep your doctor informed of your kidney and liver function, as these are closely monitored while on metformin-containing medicines, and let them know if you're due for any procedures involving contrast dye, as this medicine may need to be paused beforehand.

The usual dose is one tablet of Amaryl M SR 2/500mg taken once daily, though your doctor may start you on a lower-strength combination first and adjust the dose gradually based on your blood sugar control and kidney function. Never change your dose without your doctor's guidance, as both the glimepiride and metformin components need careful individual titration.

• Nausea or upset stomach
• Diarrhea or loose stools
• Abdominal discomfort or bloating
• Metallic taste in the mouth
• Low blood sugar (hypoglycemia), which may cause sweating, shakiness, hunger, or dizziness
• Headache
• Decreased appetite
• Reduced vitamin B12 levels with long-term use
• Skin rash or itching — uncommon
• Lactic acidosis — rare but serious; seek urgent medical attention if you experience unusual muscle pain, difficulty breathing, stomach pain, or feeling unusually cold or tired

Store Amaryl M SR 2/500mg Tablet at room temperature, generally between 20°C and 25°C, in a dry place away from direct sunlight and moisture. Keep the tablets in their original blister packaging and store them safely out of the reach and sight of children.

• Take your tablet at the same time each day with a meal to reduce stomach upset
• Swallow the tablet whole — do not crush or chew, as this is a sustained-release formulation
• Never skip a meal after taking this medicine
• Carry a fast-acting source of sugar in case of low blood sugar symptoms
• Store at room temperature, away from direct sunlight and humidity
• Keep tablets in their original blister packaging until ready to use
• Keep out of reach of children at all times
• Inform your doctor before any scheduled surgery or imaging scan involving contrast dye, as this medicine may need to be paused

Amaryl M SR 2/500mg Tablet is taken by mouth, generally once daily with a meal (commonly dinner or the evening meal, as advised by your doctor), and the tablet should be swallowed whole with a glass of water rather than crushed or chewed, since crushing a sustained-release tablet can affect how the medicine is released into your body. Taking it with food helps reduce the stomach-related side effects that can occur with the metformin component.

Amaryl M SR 2/500mg Tablet generally remains stable until the expiry date printed on the blister strip and outer carton when stored correctly and unopened. Always check this date before use and avoid taking any tablet past its expiry.

Each Amaryl M SR tablet contains Glimepiride 2 mg, a sulfonylurea that stimulates insulin release from the pancreas, combined with Metformin Hydrochloride 500 mg (sustained-release), a biguanide that reduces glucose production by the liver and improves insulin sensitivity in the body's tissues.

Known hypersensitivity to glimepiride, metformin, other sulfonylureas or biguanides, or any ingredient in the tablet
Type 1 diabetes (insulin-dependent diabetes)
Diabetic ketoacidosis or diabetic precoma/coma
Severe kidney impairment (reduced kidney function increases the risk of lactic acidosis with metformin)
Severe liver impairment
Conditions associated with tissue hypoxia, such as recent heart attack, severe heart or respiratory failure, or shock
Acute conditions that may alter kidney function, such as dehydration, severe infection, or major surgery
Pregnancy and breastfeeding
Before certain imaging procedures using iodinated contrast media, as temporary discontinuation is usually required

Alcohol may increase the risk of lactic acidosis with the metformin component and can also disrupt blood sugar control, increasing hypoglycemia risk with glimepiride
Certain antifungal medicines (such as miconazole) can cause severe hypoglycemia when combined with glimepiride
Iodinated contrast media used in certain X-ray or CT scan procedures may increase the risk of lactic acidosis and generally require temporary discontinuation of this medicine before and after the procedure
Diuretics, corticosteroids, and oral contraceptives may raise blood sugar levels, potentially reducing the medicine's effectiveness
NSAIDs (pain relievers), certain antibiotics, and beta-blockers may increase the blood-sugar-lowering effect and raise the risk of hypoglycemia
Other medicines that affect kidney function should be used with caution alongside this medicine
Always inform your doctor or pharmacist of all other prescription medicines, over-the-counter products, and supplements you're taking

Do I need a prescription to purchase Amaryl M SR 2/500mg Tablet?
Yes, Amaryl M SR is a prescription-only medicine. A valid prescription from a registered doctor is required before we can process your order.

Can I order Amaryl M SR 2/500mg Tablet online for delivery to Singapore?
Yes, once your prescription has been submitted and verified, our online pharmacy can arrange delivery to addresses in Singapore.

How do I submit my prescription when placing an order?
You can upload a photo or scanned copy of your prescription during checkout, or send it to our customer service team, who will verify it with our pharmacist before your order is confirmed.

How can I be sure the tablets I receive are genuine?
We source Amaryl M SR directly from authorised distributors, and every order is handled and shipped under proper storage conditions to help ensure the tablets arrive sealed and authentic.

How long does delivery to Singapore usually take?
Delivery timeframes depend on the shipping option selected at checkout; estimated delivery windows are shown before you confirm your order, with tracking provided once it's dispatched.

Is it safe to order long-term diabetes medication from an online pharmacy?
Ordering from a licensed pharmacy that verifies prescriptions and maintains proper storage and handling standards is a safe and convenient option for many patients on ongoing therapy.

How should I store the tablets after they arrive, given Singapore's warm and humid climate?
Keep the blister strips in their original packaging, stored at room temperature, away from direct sunlight and moisture, until you're ready to use them.

Can I set up a repeat or recurring order for my ongoing prescription?
Many customers on long-term therapy can arrange repeat orders; please check with our pharmacist team about the requirements for prescription renewal or refill scheduling.

Can I track my order once it ships to Singapore?
Yes, a tracking number is generally provided once your order is dispatched, so you can follow its progress until delivery.

What should I do if my order arrives damaged, incomplete, or close to its expiry date?
Please contact our customer service team promptly with your order number and photos of the item, and we will assist with a replacement or refund in accordance with our returns policy.